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ACE Inhibitor
Class of medicines used to treat high blood pressure and other diseases.
Activating factor
A functioning plasma protein that works in the coagulation pathway to help form a clot.
Anabolic steroid
Also referred to as attenuated androgen, a class of steroid hormones used to prevent HAE attacks. Although their mechanism of action in HAE patients is unknown, these agents are believed to partially reverse the biochemical defect by increasing levels of C1-esterase inhibitor (C1-INH), helping to prevent angioedema attacks in patients with inherited C1-INH deficiency.
Antifibrolytic agent
Medicines used to prevent HAE attacks. These agents inhibit the activation of plasmin, a chemical in the blood that can make the C1-INH less effective.
Attenuated androgen
Also referred to as anabolic steroid, a class of steroid hormones used to prevent HAE attacks. Although their mechanism of action in HAE patients is unknown, these agents are believed to partially reverse the biochemical defect by increasing levels of C1-esterase inhibitor (C1-INH), helping to prevent angioedema attacks in patients with inherited C1-INH deficiency.
Bradykinin
A protein, which when released, causes blood vessels to expand (dilate) and leak fluid, such as serum, into surrounding tissue.
C1 inhibitor
Also referred to as C1-INH, a protein found in the fluid part of your blood that controls C1, a component of your body's complement system. Abnormal swelling can result when C1-INH is insufficient or defective.
C1-INH
Also referred to as C1 inhibitor, a protein found in the fluid part of your blood that controls C1, a component of your body's complement system. Abnormal swelling can result when C1-INH is insufficient or defective.
Cleave
To cut; to split
Coagulation pathway
A process in which blood cells work together to form a clot.
Complement system
The complement system is made up of proteins like C1 that float in your bloodstream, which work with the immune system to fight organisms like bacteria, viruses and parasites.
Drug formulary
A list of prescription medications selected for coverage under a health insurance plan.
Edema
Swelling caused by an excessive amount of fluid in the body tissues.
Endothelial cells
A thin layer of cells that line the surface of blood vessels.
Enzyme
A protein that changes the rate of chemical reactions in the body.
HAE
HAE, or Hereditary Angioedema, is a rare, hereditary disease of the immune system that affects an estimated 1 in 10,000 to 1 in 50,000 adults and children globally. HAE causes attacks of spontaneous swelling that are often painful and severe, and can be life-threatening.
Hereditary Angioedema
A rare, hereditary disease of the immune system that affects an estimated 1 in 10,000 to 1 in 50,000 adults and children globally. Hereditary Angioedema (HAE) causes attacks of spontaneous swelling that are often painful and severe, and can be life-threatening.
High-molecular-weight kininogen
HMWK, a protein that acts on the inflammation and coagulation processes; inactive until it is cleaved by kallikrein and in turn, releases bradykinin.
Hypotension
Low blood pressure.
Inflammatory pathway
A process in which the body responds to an injury either inside or outside of the body.
Inhibitor
That which reduces, prevents or stops; i.e. a substance that stops enzyme activity.
Kallikrein–kinin system
A system of proteins in the blood that has a role in the inflammatory pathway; through this system, bradykinin is released.
Kinin
A protein that is a component of the kallikrein-kinin system.
Laryngeal attack
An HAE attack that affects the larynx (throat); this can block or close the airway, leading to difficulty breathing and, potentially, death.
Liberate
To release
Plasma kallikrein
An enzyme present in blood plasma, urine and tissue; responsible for cleaving high-molecular-weight kininogen (HMWK), which then releases bradykinin.
Prekallikrein
Precursor to kallikrein; inactive until it cleaved by activated factor (specifically, activated factor XII) to generate active kallikrein.
Preventive therapy
In HAE, medicine taken to prevent attacks.
Prodrome
One or more physical warnings of an HAE attack; can appear as a rash or a feeling of skin tightness.
Protease
An enzyme that breaks proteins down into a simpler form.
Proteolytic cascade
A step-by-step process in which proteins are broken down into simpler forms.
Receptor
A component in a cell that can combine with a drug or a chemical in the body (i.e. hormone) to change the function of the cell.
Serum
The clear, watery, fluid-component of blood that resembles fluid in a blister.
Subcutaneous
Beneath the skin.
Substrate
A molecule or substance acted upon by an enzyme.
Trigger
In HAE, something that causes an attack. Stress and trauma are two common HAE attack triggers.
Vascular permeability
The capacity of blood vessels to allow fluids or molecules to pass in and out of the vessel.
Vasodilator
A substance that opens, or dilates, blood vessels; e.g. bradykinin and nitric oxide.
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HAE Diagnostic Testing

Hereditary angioedema (HAE) is often unrecognized or misdiagnosed because it is a rare disease and its symptoms are similar to other more common conditions. Patients with undiagnosed HAE may undergo unnecessary medical procedures or receive ineffective treatments.

That's why Dyax Corp. (Dyax) offers two Hereditary Angioedema (HAE) Diagnostic Testing Programs to help eligible patients cover the costs of their HAE diagnostic tests. 

Option 1: Free Diagnostic Testing Program

Free Diagnostic Testing is offered to those eligible1 patients who do not wish to use their insurance for an HAE test. Dyax is excited to partner with Medivo, a health monitoring company that offers access to lab testing and delivers results directly to patients.  

Enrollment for Free Diagnostic Testing is easy:

Step 1: Select the Free Diagnostic Test option within the registration form below and fill out all required information.
Step 2: After completion and confirmation of eligibility, you will be directed to the Medivo website where you will complete your registration and obtain information on a testing site near you.

State and federal restrictions apply to the following:

  • People living in MA, MD, RI, NJ or NY
  • People who are insured and living in MI or MN
  • Those with government sponsored insurance 
  • Those under the age of 18

If you fall within any of the above categories, then you are not eligible for Free Diagnostic Testing. However, you may qualify for the Diagnostic Testing Refund Program described below. 

Option 2: Diagnostic Testing Refund Program

Dyax also offers a Diagnostic Testing Refund Program for those patients who wish to use their insurance coverage or are not eligible2 for the Free Diagnostic Testing Program, and would like to receive assistance with HAE test-related costs. Some restrictions apply. 

It is easy to enroll and start using this program. Simply follow these 4 steps:

Step 1: Request an HAE diagnostic test order from your physician.
Step 2: Call 1-855-HAEHope (1-855-423-46731-855-423-4673) or complete the form below and choose Diagnostic Testing Refund Program. A program kit will be mailed to you.
Step 3: Go to the lab your physician refers you to and get tested. You will have to pay all test related costs including copays, coinsurance, and deductibles. Be sure to obtain and keep all receipts for your payments in order to receive your refund.
Step 4: Place a copy of all HAE test receipts and a copy of your Health Insurer Explanation of Benefits in the pre-paid, pre-addressed envelope provided in the program kit and drop it in the mail.

A refund check will be mailed to you for your out-of-pocket costs related to your HAE diagnostic testing.

IMPORTANT: The person receiving the HAE diagnostic test must complete the registration form.

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By participating in Dyax’s HAE diagnostic testing refund program, I agree to share my personal information with Dyax. I consent to being contacted by mail, email, and/or telephone by Dyax and companies working with it to ask me about my experiences with, or thoughts about, products, services, and programs that Dyax offers or sponsors.

Dyax respects your privacy. Dyax will not sell, loan, trade or otherwise disseminate any personally identifiable information or health related personal information that we collect.

Please read our privacy policy for more information at http://www.haehope.com/privacy-policy.html.

1Persons enrolled in any government health care program, such as Medicare, Medicaid, or Tricare, persons residing in the Commonwealth of Massachusetts, Maryland, Rhode Island, New Jersey, or New York, persons who are insured and residing in Michigan or Minnesota, and persons under the age of 18 are not eligible to participate in Dyax's Free Diagnostic Testing Program.

2Persons enrolled in any government health care program, such as Medicare, Medicaid, or Tricare, and persons residing in the Commonwealth of Massachusetts, Minnesota, Rhode Island, or Michigan are not eligible to participate in Dyax's Diagnostic Testing Refund Program. If you are not eligible, Foundation Assistance may be available. Please call 1-855-HAEHope (1-855-423-4673) to learn more.

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